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This study compares the immune responses of healthy individuals—with or without prior SARS-CoV-2 infection—after Comirnaty (Pfizer) and Vaxzevria (AstraZeneca) vaccinations. For this study, a total cohort of 134 volunteers was analyzed. Among the 71 Comirnaty recipients, 36 had prior COVID-19, while 33 of the 63 Vaxzevria recipients had a history of infection.

本研究比较了健康人群在接种Comirnaty（辉瑞）和Vaxzevria（阿斯利康）疫苗后，无论之前是否感染过SARS-CoV-2的免疫反应。研究共分析了134名志愿者的数据。其中，71名接种Comirnaty疫苗者中有36人曾感染过COVID-19，而63名接种Vaxzevria疫苗者中有33人有感染史。

Individuals’ immune responses were assessed after second and third doses by measuring the levels of anti-SARS-CoV-2 Immunoglobulin G (IgG) and specific interferon-gamma (IFN-γ) release assay (IGRA). Statistically significant differences were observed in IgG and IFN-γ concentrations between groups receiving different vaccines.

通过测量抗SARS-CoV-2免疫球蛋白G（IgG）和特定干扰素-γ（IFN-γ）释放试验（IGRA）的水平，评估了个体在第二剂和第三剂后的免疫反应。在接受不同疫苗的组别之间，观察到IgG和IFN-γ浓度存在统计学上的显著差异。

Higher IgG levels were noted in individuals vaccinated with Comirnaty than in those vaccinated with Vaxzevria, especially after the third dose. Similarly, IFN-γ production was significantly higher in individuals who received Comirnaty vaccination, suggesting a stronger T-cell-mediated immune response.

接种Comirnaty疫苗的个体比接种Vaxzevria疫苗的个体呈现出更高的IgG水平，尤其是在第三剂之后。同样，接受Comirnaty疫苗接种的个体IFN-γ的产生显著更高，表明T细胞介导的免疫反应更强。

Prior infection influenced the magnitude of individuals’ immune responses, in that previously infected individuals displayed higher IgG and IFN-γ levels. Further hematologic analysis revealed notable differences in the two immune activation patterns between the vaccines’ immune activation patterns in terms of white blood cell counts, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).

既往感染影响了个体免疫反应的程度，因为既往感染者表现出更高的IgG和IFN-γ水平。进一步的血液学分析显示，在白细胞计数、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）方面，两种免疫激活模式之间存在显著差异。

The findings highlighted varying vaccine-induced immune responses, depending on the vaccine type, prior infection status, and the number of administered doses. These results contribute to a better understanding of the differential immune memory induced by mRNA-based and adenoviral vector–based vaccines and emphasize the importance of booster doses in maintaining robust immunity against SAR.

研究结果强调了疫苗诱导的免疫反应因疫苗类型、先前感染状态和接种剂量数量而异。这些结果有助于更好地理解基于mRNA和腺病毒载体疫苗所诱导的不同免疫记忆，并强调了加强针在维持对SAR的强大免疫力方面的重要性。