LONDON

伦敦

,

，

June 28, 2025

2025年6月28日

/PRNewswire/ --

/PRNewswire/ --

A team of international scientists has made a major leap forward in diabetes research by successfully 3D printing functional human islets using a novel bioink. Presented today at the ESOT Congress 2025, the new technology could pave the way for more effective and less invasive treatment for people living with type 1 diabetes..

国际科学家团队利用一种新型生物墨水成功3D打印出功能性人类胰岛，这在糖尿病研究领域取得了重大突破。这项新技术在2025年欧洲器官移植学会大会上发布，有望为1型糖尿病患者提供更有效且侵入性更小的治疗方案。

The breakthrough involved printing human islets – the insulin-producing clusters of cells in the pancreas – using a customised bioink made from alginate and decellularised human pancreatic tissue. This approach produced durable, high-density islet structures that remained alive and functional for up to three weeks, maintaining strong insulin responses to glucose and showing real potential for future clinical use..

这一突破涉及使用由藻酸盐和去细胞化的人类胰腺组织制成的定制生物墨水打印人类胰岛——胰腺中产生胰岛素的细胞簇。这种方法生成了持久、高密度的胰岛结构，这些结构在长达三周的时间里保持存活且功能正常，对葡萄糖维持强烈的胰岛素反应，并显示出未来临床应用的真正潜力。

Traditional islet transplants are typically infused into the liver, a process that can result in significant loss of cells and limited long-term success. In contrast, the 3D-printed islets were designed to be implanted just under the skin, a simple procedure requiring only local anaesthesia and a small incision.

传统的胰岛移植通常注入肝脏，这个过程会导致大量细胞损失，并且长期效果有限。相比之下，3D打印的胰岛被设计为植入皮下，这是一个简单的程序，只需要局部麻醉和一个小切口。

This minimally invasive approach could offer a safer and more comfortable option for patients..

这种微创方法可以为患者提供更安全、更舒适的选择。

'Our goal was to recreate the natural environment of the pancreas so that transplanted cells would survive and function better,' explained lead author Dr.

“我们的目标是重建胰腺的自然环境，以便移植的细胞能够更好地存活和发挥作用，”首席作者博士解释说。

Quentin Perrier

昆汀·佩里尔

. 'We used a special bioink that mimics the support structure of the pancreas, giving islets the oxygen and nutrients they need to thrive.'

“我们使用了一种特殊的生物墨水，它模仿了胰腺的支撑结构，为胰岛提供了茁壮成长所需的氧气和营养。”

The bioprinted islets stayed alive and healthy, with over 90% cell survival. They responded better to glucose than standard islet preparations, releasing more insulin when it was needed. By day 21, the islets showed a stronger ability to sense and react to blood sugar levels – an important sign that they could work well after being implanted.

生物打印的胰岛保持了活性和健康，细胞存活率超过90%。它们对葡萄糖的反应比标准胰岛制剂更好，在需要时释放更多的胰岛素。到第21天，这些胰岛显示出更强的感知和应对血糖水平的能力——这是它们在植入后能够良好运作的重要标志。

The constructs maintained their structure without clumping or breaking down, overcoming a common hurdle in earlier approaches..

这些结构保持了它们的形态，没有发生结块或分解，克服了早期方法中的一个常见障碍。

Additionally, the 3D-printed structures featured a porous architecture that enhanced the flow of oxygen and nutrients to the embedded islets. This design helped maintain cell health and promoted vascularisation, both of which are critical for long-term survival and function after transplantation.

此外，3D打印结构具有多孔架构，可增强氧气和营养物质流向嵌入的胰岛。该设计有助于维持细胞健康并促进血管化，这两点对于移植后的长期存活和功能都至关重要。

'This is one of the first studies to use real human islets instead of animal cells in bioprinting, and the results are incredibly promising,' noted Dr. Perrier. 'We're getting closer to creating an off-the-shelf treatment for diabetes that could one day eliminate the need for insulin injections.'

“这是最早使用真实人类胰岛而不是动物细胞进行生物打印的研究之一，其结果非常有前景，”佩里埃博士指出。“我们正在接近创造出一种现成的糖尿病治疗方法，有一天可能会消除对胰岛素注射的需求。”

SOURCE European Society for Organ Transplantation (ESOT) Congress 2025

来源：2025年欧洲器官移植学会（ESOT）大会

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