MONDAY, Sept. 8, 2025 -- Gastroesophageal reflux disease (GERD) may be associated with an increased risk for tinnitus, Meniere disease, vestibular dysfunction, and sensorineural hearing loss, according to a study published online Aug. 20 in the

2025年9月8日，星期一 —— 一项8月20日在线发表的研究表明，胃食管反流病（GERD）可能与耳鸣、梅尼埃病、前庭功能障碍和感音神经性听力损失的风险增加有关。

Journal of Multidisciplinary Healthcare

多学科医疗保健杂志

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Wen Zhao, from the Hebei Chinese Medical University in Shijiazhuang, and colleagues used genome-wide association study genetic data from individuals of European ancestry to examine the correlation between GERD, Barrett esophagus (BE), and ear disorders. Three Mendelian randomization methods were applied; causal estimates were determined using the inverse variance weighted method..

河北中医药大学的赵文及其同事利用欧洲血统个体的全基因组关联研究遗传数据，分析了胃食管反流病（GERD）、巴雷特食管（BE）与耳部疾病之间的相关性。研究应用了三种孟德尔随机化方法，并使用逆方差加权法确定因果估计值。

The researchers identified potential effects of genetically predicted GERD on ear disorders. GERD was associated with Meniere disease, sensorineural hearing loss, vestibular dysfunction, constant tinnitus, tinnitus occurring most of the time, and occasional tinnitus (odds ratios, 1.334, 1.127, 1.178, 1.019, 1.007, and 1.014, respectively).

研究人员确定了基因预测的胃食管反流病（GERD）对耳部疾病潜在影响。GERD与梅尼埃病、感音神经性听力损失、前庭功能障碍、持续性耳鸣、大部分时间出现的耳鸣以及偶尔出现的耳鸣相关（比值比分别为1.334、1.127、1.178、1.019、1.007和1.014）。

An increased risk for these ear disorders was seen in association with higher GERD levels. Elevated GERD levels were associated with a reduced likelihood of never experiencing tinnitus among individuals who never experienced tinnitus (odds ratio, 0.939). There was no causal association seen between GERD and otitis media.

这些耳部疾病的风险增加与较高的GERD水平有关。在从未经历过耳鸣的人群中，GERD水平升高降低了从不经历耳鸣的可能性（几率比，0.939）。未观察到GERD与中耳炎之间的因果关联。

No causal relationship was observed for BE with ear disorder risk..

未观察到BE与耳疾风险之间的因果关系。

'The MR analysis indicates that GERD may elevate the risk of Meniere's disease, sensorineural hearing loss, vestibular dysfunction, and tinnitus,' the authors write. 'These findings could offer valuable insights for the prevention of Meniere's disease, sensorineural hearing loss, vestibular dysfunction, and tinnitus.'.

作者写道：“MR分析表明，GERD可能会增加梅尼埃病、感音神经性耳聋、前庭功能障碍和耳鸣的风险。” “这些发现可为预防梅尼埃病、感音神经性耳聋、前庭功能障碍和耳鸣提供有价值的见解。”

Abstract/Full Text

摘要/全文

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