NEW YORK – Chinese next-generation sequencing instrumentation maker MGI Tech on Tuesday launched a new high-throughput sequencer that promises to deliver up to 35,000 human genomes at 30X coverage per year.

纽约——中国下一代测序仪制造商MGI Tech于周二推出了一款新的高通量测序仪，该仪器承诺每年可提供多达35,000个人类基因组的30倍覆盖。

Dubbed DNBSeq-T7+, the platform has a smaller footprint, higher data output, and faster speed than the company's existing high-throughput DNBSeq-T7 instrument.

被称为DNBSeq-T7+的平台比公司现有的高通量DNBSeq-T7仪器体积更小、数据输出更高、速度更快。

'T7 has been [around] for seven years. Although people love the [platform], we have to admit that there are some features that were bugging users,' said Erin Zhang, deputy director of the product and marketing center at MGI. 'So, it is time to have a new machine.'

“T7 已经有七年了。尽管人们喜欢这个平台，但我们必须承认，有一些功能一直在困扰用户，”MGI 产品与营销中心副主任张琳说道。“所以，是时候推出一台新机器了。”

Calling the T7+ the 'end of compromise' between data throughput and speed, MGI said the new platform, which has four independent flow cells, can generate more than 14 Tb of data within 24 hours, doubling the output of the original T7. The platform is capable of sequencing 35,000 standard whole human genomes a year, Zhang said.

MGI称，T7+是数据吞吐量与速度之间的“终结妥协”，并表示该新平台拥有四个独立的流动槽，可在24小时内生成超过14 Tb的数据，是原T7输出的两倍。张说，该平台每年能够对35,000个标准完整人类基因组进行测序。

In addition, the system's footprint has been reduced by one third..

此外，系统的体积减少了三分之一。

To achieve the higher output, the company redesigned the flow cell, shrinking the pitch between the DNA nanoballs (DNBs) and rearranging them into triangular arrays. As a result, it can accommodate about twice as many DNBs within the same area.

为了实现更高的输出，公司重新设计了流动池，缩小了DNA纳米球（DNBs）之间的间距，并将它们重新排列成三角形阵列。结果，在相同面积内可以容纳大约两倍的DNB。

The company also upgraded the optics system so it can cope with the increased DNB density, Zhang said, adding that the new proprietary time delay integration (TDI) camera can reduce the scanning time by 50 percent.

张说，公司还升级了光学系统，以便能够应对增加的DNB密度，并补充说新的专有时间延迟积分 (TDI) 相机可以将扫描时间减少50%。

Another major advancement is the integrated workflow, eliminating the need for manual preparation steps. The new instrument combines automated DNB generation and loading, as well as sequencing, washing, and FASTQ file generation. It can also carry out bioinformatic analysis onboard.

另一个重要的进步是集成的工作流程，消除了手动准备步骤的需要。新仪器结合了自动化的DNB生成和加载，以及测序、清洗和FASTQ文件生成。它还可以在设备上进行生物信息学分析。

In contrast, the existing T7 platform is usually sold as a trio, Zhang noted, including the DNB loader and Ztron, a standalone computing module for data handling.

相比之下，张指出，现有的T7平台通常作为三件套出售，包括DNB加载器和Ztron，一个用于数据处理的独立计算模块。

According to MGI, more than 90 percent of the reads produced by the T7+, which uses the standard MPS2.0 chemistry, have a Q40 quality score. Zhang said the company has tested samples HG001 to HG007 from the Genome in a Bottle (GIAB) consortium as part of its internal benchmarking and has found the F1-score – a measure of variant calling accuracy – for SNPs to be around 99 percent and for indels around 99.5 percent.

根据MGI的数据，使用标准MPS2.0化学试剂的T7+测序仪产生的读取数据中，超过90%具有Q40质量分数。张表示，公司已对来自“瓶中基因组”（GIAB）联盟的HG001至HG007样本进行了内部基准测试，发现SNP的F1分数（一种衡量变异检测准确性的指标）约为99%，而插入缺失（indels）的F1分数约为99.5%。

Additionally, it achieved an F1-score of almost 80 percent for structural variants (SVs). .

此外，它在结构变异（SVs）方面达到了近80%的F1分数。

While MGI claims the new platform has been 'validated in beta testing by leading labs,' it has not shown any customer data publicly or named any early-access users.

虽然MGI声称新平台“已经过领先实验室的测试验证”， 但其既没有公开任何客户数据，也没有透露任何抢先体验的用户。

At launch, the T7+ platform will support paired-end (PE) 100 and PE 150 sequencing. For PE 150 runs, the turnaround time is 24 hours, Zhang noted. The company is also developing a workflow for customers to directly load Illumina libraries.

张指出，T7+平台在发布时将支持双端（PE）100和PE 150测序。对于PE 150运行，周转时间为24小时。该公司还在开发一种工作流程，以供客户直接加载Illumina文库。

Given its high throughput, target customers for the new T7+ platform are similar to those of the T7, including academic core facilities, commercial service providers, and multiomics labs. The instrument is geared towards large-scale genomics applications such as single-cell, spatial, population genomics, and cancer studies.

鉴于其高通量，新T7+平台的目标客户与T7类似，包括学术核心设施、商业服务提供商和多组学实验室。该仪器面向大规模基因组学应用，如单细胞、空间、群体基因组学和癌症研究。

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For existing T7 customers, Zhang said, there will be a trade-in program if they want to upgrade to the new platform. However, she declined reveal the per-Gb sequencing cost or the list price for the T7+. Previously, Complete Genomics, MGI's US subsidiary, said T7 is able to generate 20,000 30X whole genomes in one year at $150 per genome, or $1.5 per Gb.

对于现有的T7客户，张说，如果他们想升级到新平台，将有一个以旧换新计划。但是，她拒绝透露每Gb测序成本或T7+的定价。此前，MGI的美国子公司Complete Genomics表示，T7一年内能够以每个基因组150美元或每Gb 1.5美元的价格生成20,000个30倍覆盖率的全基因组。

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The T7+ is available for order globally. It will ship within mainland China immediately and outside of China in Q4. According to Zhang, the company already has 'a few shipments' in China scheduled for early-access customers. During a launch event hosted by BGI Group on Tuesday in Shenzhen, which was livestreamed on Chinese social media, MGI said it has secured the first batch of orders from customers including BGI Genomics, GenePlus, and BerryGenomics.

T7+在全球范围内接受订购。它将立即在中国大陆发货，并在第四季度在中国以外地区发货。据张说，公司已经安排了“一些发运”给中国的早期访问客户。在周二于深圳由华大集团主办并在中文社交媒体上直播的发布会上，MGI表示已从包括华大基因、基因加和贝瑞基因在内的客户那里获得了第一批订单。

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It is unclear how the US tariffs will impact exports of the T7+ to the US, and whether the company will choose to manufacture the new platform in its San Jose, California facility. Zhang said the firm is 'in discussions' for the production site of platforms for the US market.

目前还不清楚美国的关税将如何影响T7+出口到美国，以及该公司是否会选在其加州圣何塞的工厂制造这个新平台。张说，公司正在商讨面向美国市场平台产品的生产地问题。

With the launch of the T7+, MGI clearly targets high-throughput customers that may also be interested in Ultima Genomics' UG 100 and Illumina's NovaSeq. At this year's Advances in Genome Biology and Technology (AGBT) annual meeting in February, the company also launched a new mid-throughput sequencer, .

随着T7+的推出，MGI显然瞄准了可能对Ultima Genomics的UG 100和Illumina的NovaSeq也感兴趣的高通量客户。在今年2月举行的基因组生物学和技术进展（AGBT）年会上，该公司还推出了一款新的中通量测序仪。

DNBSeq-T1+

DNBSeq-T1+

, an upgrade of the existing mid-throughput DNBSeq-G400 instrument.

，现有中通量DNBSeq-G400仪器的升级版。

T7+ and T1+ further strengthen MGI's so-called 'Seq All' roadmap, Zhang said, a tagline that the company unveiled for its sequencing products last year after BGI Group granted it the exclusive license to distribute its

张说，T7+ 和 T1+ 进一步加强了 MGI 的所谓 “Seq All” 路线图，这是该公司去年在华大集团授予其独家分销许可后为其测序产品推出的口号。

CycloneSeq

循环序列

long-read nanopore sequencers.

长读长纳米孔测序仪。

According to Zhang, MGI currently offers two CycloneSeq platforms, G100-ER and G400-ER, for lower and higher throughput, respectively. However, their commercial deployment overseas has already

据张介绍，MGI目前提供两款CycloneSeq平台，分别为低通量的G100-ER和高通量的G400-ER。不过，它们在海外的商业部署已经展开。

struck a nerve

触碰到神经

with Oxford Nanopore Technologies.

与牛津纳米孔技术公司合作。

So far, the company has shipped more than 300 CycloneSeq sequencers, mostly in China but also in Asia-Pacific and Europe, though Zhang declined to disclose specific countries.

迄今为止，该公司已经交付了300多台CycloneSeq测序仪，主要在中国，但在亚太和欧洲也有，不过张拒绝透露具体的国家。