by Mark Chiang

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Eli Lilly recently acquired Verve Therapeutics, including its PCSK9-targeting candidate. This development highlights the growing interest in PCSK9 as a therapeutic target, which has evolved from antibody-based treatments to potential gene-editing approaches. The acquisition underscores the pharmaceutical industry’s focus on innovative strategies for addressing cardiovascular diseases through advanced genetic technologies..

礼来公司最近收购了Verve Therapeutics，包括其针对PCSK9的候选药物。这一进展突显了PCSK9作为治疗靶点的日益增长的兴趣，已经从基于抗体的治疗方法发展到潜在的基因编辑方法。此次收购强调了制药行业通过先进基因技术应对心血管疾病的创新策略的关注。

PCSK9, a protein involved in cholesterol regulation, has been a key target for therapies aimed at reducing LDL cholesterol levels. Initial treatments focused on monoclonal antibodies that inhibit PCSK9 activity, effectively lowering cholesterol and reducing cardiovascular risk. More recently, research has shifted toward gene-editing techniques that aim to provide longer-lasting solutions by directly modifying the genes responsible for PCSK9 production.

PCSK9是一种参与胆固醇调节的蛋白质，一直是降低LDL胆固醇水平疗法的关键目标。初期治疗聚焦于抑制PCSK9活性的单克隆抗体，有效降低了胆固醇并减少了心血管风险。最近，研究转向了基因编辑技术，旨在通过直接修改负责PCSK9生成的基因，提供更持久的解决方案。

Eli Lilly’s investment in Verve Therapeutics reflects this shift and signals continued exploration of genetic approaches to tackle heart disease..

礼来公司对Verve Therapeutics的投资反映了这一转变，并表明将继续探索应对心脏病的基因方法。

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Date: October 22, 2025

日期：2025年10月22日

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Mark Chiang

马克·蒋

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