DURHAM, NC, November 11, 2025 / Biotech Newswire / --

北卡罗来纳州达勒姆，2025年11月11日 /生物技术新闻社/ --

EpiCypher®

EpiCypher®

, a leader in chromatin biology and epigenetics, today announced the launch of its CUTANA® Fiber-seq Kit and the exclusive licensing of key Fiber-seq technology from the Altius Institute for Biomedical Sciences. This milestone marks a major step toward making advanced chromatin fiber mapping technology accessible to researchers around the world..

，染色质生物学和表观遗传学领域的领导者，今天宣布推出其CUTANA® Fiber-seq试剂盒，并从Altius生物医学科学研究所独家授权了关键的Fiber-seq技术。这一里程碑标志着向全球研究人员提供先进的染色质纤维图谱技术迈出了重要一步。

Fiber-seq, developed at Altius by Drs. John A. Stamatoyannopoulos and Andrew B. Stergachis, is a breakthrough single-molecule sequencing method that reveals how DNA and chromatin are organized and regulated. By simultaneously profiling chromatin accessibility, DNA methylation, protein footprints, and genetic variation along individual DNA molecules, Fiber-seq provides an unprecedented, multiomic view of genome function..

Fiber-seq是由John A. Stamatoyannopoulos博士和Andrew B. Stergachis博士在Altius开发的一种突破性的单分子测序方法，揭示了DNA和染色质是如何组织和调控的。通过同时分析单个DNA分子上的染色质可及性、DNA甲基化、蛋白质足迹和遗传变异，Fiber-seq提供了前所未有的基因组功能多组学视角。

The new EpiCypher CUTANA Fiber-seq Kit provides all essential reagents to take samples from cells to purified genomic DNA ready for library preparation and is fully compatible with both PacBio and Oxford Nanopore Technologies sequencing platforms. The kit simplifies the complete Fiber-seq workflow, lowering barriers to adoption and ensuring consistent, high-quality results.

新型 EpiCypher CUTANA Fiber-seq 试剂盒提供了从细胞取样到纯化基因组 DNA 的所有必要试剂，适用于 PacBio 和 Oxford Nanopore Technologies 测序平台。该试剂盒简化了完整的 Fiber-seq 工作流程，降低了使用门槛，并确保一致且高质量的结果。

It leverages EpiCypher’s exclusive Hia5 enzyme, a highly active, low-bias adenine methyltransferase, which enables precise and reproducible labeling of chromatin accessibility across the genome..

它利用了EpiCypher独有的Hia5酶，这是一种高活性、低偏差的腺嘌呤甲基转移酶，能够实现全基因组范围内染色质可及性的精确且可重复的标记。

This product launch builds on EpiCypher’s earlier release of the Hia5 enzyme and Fiber-seq services, further expanding access to the technology and providing researchers with a complete solution, from reagents and experimental support to long-read sequencing analysis.

本次产品发布基于EpiCypher此前推出的Hia5酶和Fiber-seq服务，进一步扩大了对该技术的访问，并为研究人员提供了从试剂和实验支持到长读长测序分析的完整解决方案。

“Fiber-seq is transforming how we connect genetic variation to epigenetic signatures that define gene regulation, drug response, and disease,”

“Fiber-seq 正在改变我们如何将遗传变异与定义基因调控、药物反应和疾病的表观遗传特征联系起来。”

said Martis Cowles, Chief Business Officer, EpiCypher.

EpiCypher首席商务官马蒂斯·考尔斯说道。

“By providing a single-molecule view of chromatin structure and methylation, this technology offers a powerful new platform for drug development and diagnostic discovery, linking the genome’s sequence to its functional output for the first time.”

“通过提供染色质结构和甲基化的单分子视图，这项技术为药物开发和诊断发现提供了一个强大的新平台，首次将基因组序列与其功能输出联系起来。”

Through a growing collaboration, EpiCypher and PacBio are helping researchers adopt Fiber-seq by combining advanced chromatin biochemistry with highly accurate long-read sequencing. Early enthusiasm from the long-read sequencing community underscores Fiber-seq’s potential to illuminate new aspects of genome and epigenome function..

通过不断加深的合作，EpiCypher 和 PacBio 正在帮助研究人员采用 Fiber-seq 技术，将先进的染色质生物化学与高度精确的长读长测序相结合。长读长测序社区的早期热情突显了 Fiber-seq 在揭示基因组和表观基因组功能新方面方面的潜力。

“The Fiber-seq kit from EpiCypher is an exciting demonstration of how PacBio’s highly accurate long-read sequencing can deliver unparalleled insight into both the genome and epigenome,”

“EpiCypher 的 Fiber-seq 试剂盒令人兴奋地展示了 PacBio 的高精度长读长测序如何能够提供对基因组和表观基因组的无与伦比的洞察。”

said Dave Miller, Vice President Global Marketing, PacBio.

太平洋生物科学公司全球营销副总裁戴夫·米勒表示。

“We’re excited that EpiCypher is expanding access to this innovation and offering Fiber-seq services using PacBio’s Revio sequencer. Together, we are enabling researchers to unlock deeper biological understanding with a single, comprehensive multiomic assay that goes beyond just 5-base sequencing.”.

“我们很高兴EpiCypher正在扩大对该创新技术的访问，并使用PacBio的Revio测序仪提供Fiber-seq服务。我们共同使研究人员能够通过一个全面的多组学检测，解锁更深层次的生物学理解，而不仅仅局限于5碱基测序。”

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About

关于

EpiCypher

EpiCypher

EpiCypher was founded in response to the growing demand for high-quality reagents to study chromatin regulation and enable epigenetics-focused drug discovery. The company is at the forefront of chromatin mapping technologies with the CUTANA

EpiCypher公司成立是为了满足对高质量试剂日益增长的需求，以研究染色质调控并推动以表观遗传学为重点的药物发现。该公司处于染色质定位技术的前沿，拥有CUTANA平台。

®

®

platform for ultra-sensitive CUT&RUN, CUT&Tag, Fiber-seq and DNA methylation profiling assays. EpiCypher also offers the largest collection of defined designer nucleosomes (dNucs) on the market along with complementary high-throughput assays and services. EpiCypher is dedicated to bringing these transformative technologies to market and offers superior products and assay services to researchers worldwide. .

超灵敏CUT&RUN、CUT&Tag、Fiber-seq和DNA甲基化分析平台。EpiCypher还提供市场上种类最全的设计核小体（dNucs），以及配套的高通量检测和服务。EpiCypher致力于将这些变革性技术推向市场，为全球研究人员提供卓越的产品和检测服务。

EpiCypher and CUTANA are registered trademarks of EpiCypher, Inc.

EpiCypher 和 CUTANA 是 EpiCypher, Inc. 的注册商标。

Contact

联系

EpiCypher

EpiCypher

Janna Badalian

扬娜·巴达良

+1 919-520-9792

+1 919-520-9792

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Keywords: Chromatin; Epigenomics; Histone Code; Gene Expression; Drug Discovery; EpiCypher; Fiber-seq; CUTANA Fiber-seq Kit; chromatin mapping; DNA methylation; protein footprints; genetic variation; genome function; PacBio; chromatin accessibility; genetic variation; epigenetic signatures; gene regulation; drug response; chromatin structure; methylation; drug development; diagnostic discovery; genome sequence; PacBio Revio sequencer; genome function; epigenome function; chromatin regulation; CUT&RUN; CUT&Tag; DNA methylation profiling.

关键词：染色质；表观基因组学；组蛋白密码；基因表达；药物发现；EpiCypher；Fiber-seq；CUTANA Fiber-seq 试剂盒；染色质图谱；DNA 甲基化；蛋白质足迹；遗传变异；基因组功能；PacBio；染色质可及性；遗传变异；表观遗传标记；基因调控；药物反应；染色质结构；甲基化；药物开发；诊断发现；基因组序列；PacBio Revio 测序仪；基因组功能；表观基因组功能；染色质调控；CUT&RUN；CUT&Tag；DNA 甲基化分析。

Source: Biotech Newswire

来源：生物技术新闻