Study Finds Rigid Gas-Permeable Lenses Improve Vision After Congenital Glaucoma Surgery in Children

研究发现，先天性青光眼手术后，硬性透气隐形眼镜可改善儿童视力

November 27, 2025

2025年11月27日

Children who undergo surgery for primary congenital glaucoma (PCG) may experience significantly better visual outcomes when fitted with rigid gas-permeable contact lenses (RGPCLs) compared to spectacles, according to a randomized clinical trial published in JAMA Ophthalmology.

根据发表在《JAMA眼科》上的一项随机临床试验，接受原发性先天性青光眼（PCG）手术的儿童，如果佩戴硬性透气性隐形眼镜（RGPCLs），相比眼镜可能会获得显著更好的视觉效果。

Comparative Study: RGPCLs vs. Spectacles

比较研究：RGPCL与眼镜

The study, led by Jinyun Jiang, MD, PhD, from the State Key Laboratory of Ophthalmology in Guangzhou, China, evaluated the visual improvement potential of RGPCLs in pediatric PCG patients aged 4 to 15 who had shown a poor response to spectacle correction following glaucoma surgery.

这项研究由来自中国广州眼科学国家重点实验室的姜金云博士（医学博士、哲学博士）领导，评估了硬性透气性接触镜（RGPCLs）在4至15岁对眼镜矫正反应不佳的先天性青光眼（PCG）儿童患者中的视力改善潜力。

A total of 56 children with surgically managed PCG were enrolled. Participants were randomly assigned to either the RGPCL group (n = 29) or the spectacle group (n = 27). All participants received standardized amblyopia patching therapy in addition to their respective corrective devices and were followed over a 12-month period..

共有56名接受手术治疗的PCG儿童入选。参与者被随机分配到RGPCL组（n = 29）或眼镜组（n = 27）。所有参与者除了使用各自的矫正设备外，还接受了标准化的弱视遮盖治疗，并在12个月内进行了随访。

Key Findings: Improved Visual Acuity and Contrast Sensitivity

关键发现：视力和对比敏感度的提升

At baseline, the mean worse-eye spherical equivalents were −6.55 diopters in the RGPCL group and −5.17 diopters in the spectacle group. Baseline best corrected visual acuity (BCVA) was similar between groups at 0.99 and 1.02 logMAR, respectively (equivalent to approximately 20/200 Snellen).

在基线时，RGPCL组的平均较差眼球镜度数为-6.55屈光度，而眼镜组为-5.17屈光度。基线最佳矫正视力（BCVA）在两组中分别为0.99和1.02 logMAR（相当于大约20/200的斯内伦视力），相似。

After one year:

一年后：

• BCVA improvement was significantly greater in the RGPCL group (mean improvement of 0.31 logMAR) compared to the spectacle group (0.12 logMAR).

• RGPCL组的BCVA改善显著大于眼镜组（RGPCL组平均改善0.31 logMAR，眼镜组为0.12 logMAR）。

• 62.5% of children in the RGPCL group gained two or more lines of BCVA, compared with 37.5% in the spectacle group (odds ratio: 6.83).

• RGPCL组中62.5%的儿童获得了两行或以上的BCVA，而眼镜组为37.5%（比值比：6.83）。

• The RGPCL group showed greater improvement in contrast sensitivity function (0.40 vs. 0.13).

• RGPCL组在对比敏感度功能方面表现出更大的改善（0.40 vs. 0.13）。

• Near stereoacuity of 60 arcseconds or better was achieved by 50.0% in the RGPCL group, compared to 25.0% in the spectacles group (odds ratio: 6.96).

• RGPCL组中有50.0%的患者达到了60弧秒或更好的近立体视锐度，而眼镜组中仅有25.0%（比值比：6.96）。

Safety Profile and Clinical Implications

安全性概况与临床意义

Importantly, no serious adverse events were reported in either group during the trial. The researchers concluded that RGPCLs represent a safe and effective alternative to spectacles for children with PCG who respond poorly to conventional corrective lenses.

重要的是，在试验期间，两组均未报告严重的不良事件。研究人员得出结论，对于对传统矫正镜片反应不佳的PCG儿童，RGPCLs 是一种安全有效的替代眼镜的选择。

Reference:

参考：

Jinyun Jiang et al, Visual Outcomes of Children With Primary Congenital Glaucoma Receiving Different Refractive Corrections, JAMA Ophthalmology (2025). DOI: 10.1001/jamaophthalmol.2025.3976

江金云等，《接受不同屈光矫正的原发性先天性青光眼儿童的视觉结果》，《JAMA眼科》（2025）。DOI：10.1001/jamaophthalmol.2025.3976