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A recent preclinical study has reported significant findings regarding the treatment of HER2-positive cancers. Researchers investigated the combined use of a radiolabelled HER2-targeting single-domain antibody and the PARP inhibitor Olaparib, revealing synergistic effects between these two therapeutic approaches.

最近的一项临床前研究报道了关于HER2阳性癌症治疗的重要发现。研究人员调查了放射性标记的HER2靶向单域抗体与PARP抑制剂奥拉帕尼的联合使用，揭示了这两种治疗方法之间的协同效应。

The study, led by Dewulf, Navarro, and Dumauthioz, focused on exploring how this combination could enhance treatment efficacy in HER2-positive cancer models..

这项由德乌尔夫、纳瓦罗和杜马蒂奥兹领导的研究，专注于探索这种组合如何提高HER2阳性癌症模型中的治疗效果。

The research highlights that integrating the radiolabelled HER2 antibody with Olaparib may amplify therapeutic outcomes by targeting cancer cells more effectively. HER2-positive cancers are characterized by overexpression of the human epidermal growth factor receptor 2 (HER2), which drives aggressive tumor growth.

研究表明，将放射性标记的HER2抗体与奥拉帕尼结合使用，可以通过更有效地靶向癌细胞来增强治疗效果。HER2阳性癌症的特征是人表皮生长因子受体2（HER2）的过度表达，这种过度表达会促使肿瘤快速生长。

The study utilized preclinical models to examine how combining these treatments impacts tumor response. Findings suggest that the radiolabelled antibody specifically targets HER2-expressing cells while Olaparib inhibits PARP enzymes involved in DNA repair mechanisms within cancer cells. Together, this dual approach appears to create a stronger anti-cancer effect than either therapy alone.

该研究利用临床前模型来检查结合这些治疗方法对肿瘤反应的影响。研究结果表明，放射性标记的抗体专门针对表达HER2的细胞，而奥拉帕尼抑制癌细胞内参与DNA修复机制的PARP酶。这种双重方法结合在一起似乎比单独使用任何一种疗法产生更强的抗癌效果。

Further studies are expected to assess its potential for clinical application in treating patients with HER2-positive cancers..

预计将进一步开展研究，以评估其在治疗HER2阳性癌症患者中的临床应用潜力。

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Source: GO-AI-ne1

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Date: December 14, 2025

日期：2025年12月14日

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