与多囊卵巢综合症慢性炎症和排卵功能障碍相关的基质金属蛋白酶-9-动脉网

Matrix Metalloproteinase-9 Linked to Chronic Inflammation and Ovulatory Dysfunction in Polycystic Ovary Syndrome

GeneOnline 等信源发布 2025-12-15 21:45

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Recent research has identified matrix metalloproteinase-9 (MMP-9) as a key factor in the pathophysiology of polycystic ovary syndrome (PCOS), one of the most common reproductive endocrine disorders affecting women of childbearing age. Studies indicate that dysregulation of MMP-9 is linked to chronic inflammation and ovulatory dysfunction, shedding light on potential mechanisms underlying the condition..

最近的研究已经确定基质金属蛋白酶-9（MMP-9）是多囊卵巢综合征（PCOS）病理生理学中的一个关键因素，这是影响育龄妇女的最常见的生殖内分泌疾病之一。研究表明，MMP-9的失调与慢性炎症和排卵功能障碍有关，揭示了该病症潜在机制的线索。

PCOS is characterized by hormonal imbalances, irregular menstrual cycles, and metabolic complications. Researchers have focused on MMP-9 due to its role in tissue remodeling and inflammatory processes. Findings suggest that elevated levels or improper regulation of MMP-9 may contribute to the chronic inflammation observed in PCOS patients, which could disrupt normal ovarian function and lead to ovulatory issues.

PCOS 的特征是荷尔蒙失衡、月经周期不规律以及代谢并发症。研究人员关注 MMP-9，是因为它在组织重塑和炎症过程中起作用。研究结果表明，MMP-9 水平升高或调节不当可能促成 PCOS 患者所观察到的慢性炎症，这可能会扰乱正常的卵巢功能并导致排卵问题。

These insights provide a deeper understanding of how molecular pathways might influence reproductive health in individuals with PCOS..

这些见解提供了关于分子通路如何影响多囊卵巢综合征（PCOS）个体生殖健康的更深入理解。

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Date: December 15, 2025

日期：2025年12月15日

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