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Researchers have developed a targeted mRNA therapy aimed at improving treatment for liver cancer, according to findings published in *Nature Communications*. The study, led by scientists Huang, Liu, and Zhang, focuses on the organ-specific delivery of an mRNA-encoded bispecific T cell engager (BiTE) designed to target glypican-3 (GPC3), a protein commonly expressed in liver cancer cells.

研究人员开发出一种针对肝癌治疗的靶向mRNA疗法，研究成果发表在《自然通讯》上。这项由黄、刘和张三位科学家领导的研究，专注于器官特异性递送一种编码双特异性T细胞衔接器（BiTE）的mRNA，该BiTE旨在靶向磷脂酰肌醇蛋白聚糖-3（GPC3），这是一种在肝癌细胞中常见表达的蛋白质。

This approach seeks to enhance the immune system’s ability to identify and attack cancerous cells while minimizing off-target effects..

这种方法旨在增强免疫系统识别和攻击癌细胞的能力，同时尽量减少脱靶效应。

The research highlights the potential of using mRNA technology to deliver BiTEs directly to the liver. BiTEs are engineered molecules that link T cells—key players in the immune system—to specific proteins found on tumor cells. In this case, GPC3 serves as the target protein due to its prevalence in hepatocellular carcinoma, a common form of liver cancer.

研究强调了使用mRNA技术将BiTEs直接递送到肝脏的潜力。BiTEs是经过工程改造的分子，能够将免疫系统中的关键角色——T细胞，与肿瘤细胞上的特定蛋白质连接起来。在本研究中，由于GPC3在肝细胞癌（一种常见的肝癌形式）中广泛存在，因此被作为目标蛋白。

By encoding these BiTEs into mRNA and delivering them selectively to the liver, researchers aim to activate T cells locally within the tumor environment. This method could reduce systemic side effects often associated with immunotherapy treatments while maintaining therapeutic efficacy..

通过将这些双特异性T细胞衔接器（BiTEs）编码到mRNA中，并选择性地将其递送到肝脏，研究人员旨在激活肿瘤环境中的局部T细胞。这种方法可以在保持治疗效果的同时，减少通常与免疫疗法相关的全身副作用。

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Date: December 15, 2025

日期：2025年12月15日

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