NASHVILLE, Tenn.

田纳西州纳什维尔

,

，

April 2, 2026

2026年4月2日

/PRNewswire/ -- TAM Global today announced the publication of a new peer-reviewed paper in

/PRNewswire/ -- TAM环球今天宣布在新的同行评审论文中发布

Translational Insights

转化洞察

led by Chief Scientific Officer Dr. Francesco M. Marincola and collaborators from TAM Biosciences.

由首席科学官弗朗西斯科·M·马里诺拉博士和TAM生物科学公司的合作者们领导。

The paper,

论文，

The Perfect Storm: Viral Mimicry Meets Cancer Dark Matter,

完美风暴：病毒模拟遇上癌症暗物质，

presents a novel, unifying theory explaining how the immune system recognizes and responds to cancer—addressing a long-standing question in oncology and immunology.

提出了一种新颖的、统一的理论，解释了免疫系统如何识别和应对癌症——解决了肿瘤学和免疫学中的一个长期存在的问题。

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Translational Insights

转化医学见解

The research discusses two novel mechanisms that could fundamentally enhance the immune system's ability to detect and target cancer—revealing powerful new pathways for next-generation cancer therapies. First, cancer cells can sometimes behave like virus-infected cells, sending signals that alert the immune system, a phenomenon known as 'viral mimicry'.

该研究探讨了两种可以从根本上增强免疫系统检测和靶向癌症能力的新机制，揭示了下一代癌症治疗的强大新途径。首先，癌细胞有时会表现得像病毒感染的细胞，发出警示免疫系统的信号，这种现象被称为“病毒模拟”。

Second, tumors can produce previously unrecognized antigens arising from noncoding regions of the genome, referred to as 'cancer dark matter', which can provide the immune system with new ways to identify cancer cells..

第二，肿瘤可以产生以前未被识别的抗原，这些抗原来自基因组的非编码区域，被称为“癌症暗物质”，这可以为免疫系统提供识别癌细胞的新方法。

'This manuscript is among the first published in

“这份手稿是最早发表的之一

Translational Insights

转化洞察

, the journal I co-founded with Professor Yang Liang, and reflects its core mission,' said

“这份期刊是我与杨亮教授共同创立的，反映了其核心使命，”他说。

Dr. Francesco Marincola.

弗朗西斯科·马里诺拉博士。

'While we continue to publish rigorous, confirmatory studies, we are equally committed to advancing bold, emerging ideas that challenge current understandings of human biology and spark new directions in research.'

“在我们继续发表严谨的、验证性的研究的同时，我们也同样致力于推进大胆的、新兴的思想，这些思想挑战了当前对人类生物学的理解，并激发了研究的新方向。”

The authors suggest that the immune system defeats cancer not because of a single factor, but when several conditions occur at the same time. Viral mimicry can act as an alarm signal that activates immune defenses, while antigens from 'cancer dark matter' can provide the immune system with new targets to attack.

作者认为，免疫系统击败癌症并不是因为单一因素，而是当几种情况同时发生时。病毒模拟可以充当激活免疫防御的警报信号，而来自“癌症暗物质”的抗原则可以为免疫系统提供新的攻击目标。

When these signals occur together, they create what the authors describe as a 'perfect storm' for enabling the immune system to destroy cancer cells..

当这些信号同时出现时，它们创造了作者所说的“完美风暴”，使免疫系统能够摧毁癌细胞。

'This work reframes how we think about cancer immunogenicity,' said

“这项工作重新定义了我们对癌症免疫原性的看法，”

Ed Clay,

埃德·克莱，

CEO and Co-Founder of TAM Global. 'By integrating viral mimicry and cancer 'dark matter' into a single model, we are opening new pathways for therapeutic development and more effective immunotherapy strategies.'

TAM全球公司的首席执行官兼联合创始人表示：“通过将病毒模拟和癌症‘暗物质’整合到一个模型中，我们正在开辟治疗开发的新途径和更有效的免疫治疗策略。”

The publication underscores TAM Global's commitment to advancing translational science by bridging foundational biological insights with clinical application. The findings have potential implications across cancer immunotherapy, biomarker discovery, and next-generation therapeutic design.

该出版物强调了TAM Global致力于通过将基础生物学见解与临床应用相结合来推动转化科学的发展。这些发现可能对癌症免疫治疗、生物标志物发现和下一代治疗设计产生影响。

Read the

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full paper here

完整论文在此

About TAM Global

关于TAM环球

TAM Global is a leading translational science company dedicated to developing evidence-based cell therapies built on rigorous biology, standardized characterization, and validated clinical outcomes. With research operations in Boston, Nashville and Tijuana, TAM Global is a multidisciplinary team of 16 PhD scientists and 42 Medical doctors with a decade-long commitment to advancing regenerative medicine and cancer therapeutics.

TAM Global是一家领先的转化科学公司，致力于开发基于严格生物学、标准化特征和经过验证的临床结果的循证细胞疗法。公司在波士顿、纳什维尔和蒂华纳设有研究机构，TAM Global拥有一支由16名博士科学家和42名医学博士组成的多学科团队，他们在过去十年中一直致力于推进再生医学和癌症治疗。

TAM Global is setting new benchmarks for safety, reproducibility, and scientific integrity in the global cell therapy landscape..

TAM Global正在全球细胞治疗领域树立安全、可重复性和科学完整性的新标杆。

SOURCE The TAM Center

来源：TAM中心

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