Medical News

医学新闻

: A naturally occurring molecule inside the human body is now drawing major scientific attention for its powerful effects on aging, inflammation, and even chronic disease. Known as alpha-ketoglutarate (AKG), this compound plays a central role in how cells produce energy and respond to stress. New research is revealing that its influence extends far beyond basic metabolism, potentially opening doors to new therapies for a wide range of conditions..

：一种人体内自然存在的分子因对衰老、炎症甚至慢性疾病具有强大作用而受到科学界的广泛关注。这种化合物被称为α-酮戊二酸（AKG），在细胞产生能量和应对压力的过程中发挥着核心作用。新的研究表明，它的影响远远超出了基本代谢的范畴，可能为多种疾病的治疗打开新的大门。

A natural cellular molecule shows promise in slowing aging and reducing inflammation across

一种天然的细胞分子显示出减缓衰老和减少炎症的潜力。

multiple body systems

多个身体系统

What Is AKG and Why It Matters

什么是AKG及其重要性

AKG is a key component of the body’s energy system, specifically within the tricarboxylic acid cycle, which helps cells generate fuel. But scientists now understand that AKG is not just about energy. It also acts as a signaling molecule, helping cells regulate inflammation, repair damage, and even control how genes are switched on or off..

AKG 是人体能量系统的关键组成部分，特别是在三羧酸循环中，它有助于细胞产生能量。但科学家们现在了解到，AKG 不仅仅与能量有关。它还充当信号分子，帮助细胞调节炎症、修复损伤，甚至控制基因的开启或关闭方式。

Researchers from the Department of Orthopaedics at Emory University School of Medicine in the United States explain that AKG connects multiple critical processes inside the body. These include mitochondrial function, immune response, and epigenetic regulation, which determines how genes behave without changing DNA itself..

美国埃默里大学医学院骨科系的研究人员解释说，AKG 能够连接体内多个关键过程，包括线粒体功能、免疫反应和表观遗传调控（表观遗传调控决定基因在 DNA 本身不发生变化的情况下如何表现）。

A Powerful Anti-Inflammatory Agent

一种强效的抗炎剂

One of the most exciting discoveries is AKG’s ability to reduce chronic inflammation. It works by lowering harmful molecules known as reactive oxygen species and suppressing inflammatory pathways such as NF-kB. At the same time, it encourages the activity of anti-inflammatory immune cells.

最令人兴奋的发现之一是AKG能够减少慢性炎症。它通过降低被称为活性氧物种的有害分子并抑制诸如NF-kB之类的炎症通路来发挥作用。同时，它还促进抗炎免疫细胞的活性。

This

这

Medical News

医学新闻

report highlights that AKG can shift immune cells called macrophages from a pro-inflammatory state to a healing, anti-inflammatory state. This balance is crucial in conditions like arthritis, where inflammation damages joints over time.

报告强调，AKG能够将称为巨噬细胞的免疫细胞从促炎状态转变为愈合、抗炎状态。在这种平衡在关节炎等情况下至关重要，因为炎症会随着时间的推移损害关节。

In laboratory and animal studies, AKG was shown to reduce inflammatory chemicals while promoting tissue repair. It also helped maintain healthier cartilage and reduced joint degradation, suggesting potential benefits for people with osteoarthritis and autoimmune diseases.

在实验室和动物研究中，AKG 被证明可以减少炎症化学物质，同时促进组织修复。它还有助于维持更健康的软骨并减少关节退化，这表明它可能对患有骨关节炎和自身免疫性疾病的人有益。

Role In Aging and Longevity

衰老与长寿中的作用

Another remarkable finding is AKG’s connection to aging. Levels of this molecule naturally decline as people grow older, which may contribute to age-related diseases and reduced cellular function.

另一个引人注目的发现是AKG与衰老的联系。随着人们年龄的增长，这种分子的水平自然下降，这可能导致与年龄相关的疾病和细胞功能的减退。

Studies have shown that supplementing AKG can improve markers linked to longevity. In animal models, it reduced age-related inflammation, improved physical function, and even extended lifespan. These effects are believed to be linked to its ability to regulate pathways such as mTOR, which plays a key role in aging and metabolism..

研究表明，补充AKG可以改善与长寿相关的标志物。在动物模型中，它减少了与年龄相关的炎症，改善了身体功能，甚至延长了寿命。这些效应被认为与其调节mTOR等通路的能力有关，mTOR在衰老和代谢中起关键作用。

AKG also helps maintain a more “youthful” cellular environment by influencing gene activity through epigenetic mechanisms. This means it may help cells function more efficiently even as the body ages.

AKG 还通过表观遗传机制影响基因活动，帮助维持更加“年轻”的细胞环境。这意味着即使随着身体衰老，它也可能帮助细胞更高效地运作。

gt;

大于；

Surprising Effects on Brain and Cancer

大脑和癌症的惊人影响

AKG’s benefits are not limited to inflammation and aging. In the brain, it serves as a building block for important neurotransmitters like glutamate and GABA, which are essential for memory and nerve function. It also helps protect brain cells from oxidative stress and damage.

AKG 的益处不仅限于炎症和衰老。在大脑中，它是谷氨酸和 γ-氨基丁酸 (GABA) 等重要神经递质的组成部分，这些神经递质对记忆和神经功能至关重要。它还有助于保护脑细胞免受氧化应激和损伤。

However, researchers caution that AKG’s role in diseases like cancer is complex. In some cases, it may help suppress tumor growth by correcting harmful metabolic imbalances. In others, cancer cells may use AKG to fuel their growth. This dual role means more research is needed before it can be widely used in cancer treatment..

然而，研究人员警告说，AKG 在癌症等疾病中的作用十分复杂。在某些情况下，它可能通过纠正有害的代谢失衡来帮助抑制肿瘤生长；而在其他情况下，癌细胞可能利用 AKG 来促进自身生长。这种双重作用意味着，在广泛应用于癌症治疗之前，还需要进行更多的研究。

Potential As a Dietary Supplement

作为膳食补充剂的潜力

AKG is already being explored as a dietary supplement, often combined with other compounds such as calcium or arginine. Early studies suggest it may improve immune health, support muscle function, and enhance overall metabolic balance.

AKG 作为一种膳食补充剂已经被广泛研究，常与钙或精氨酸等其他化合物结合使用。早期研究表明，它可能有助于改善免疫健康、支持肌肉功能并增强整体代谢平衡。

Different forms of AKG, including ornithine alpha-ketoglutarate, have shown promise in reducing inflammation and improving gut health in both animal and human studies. However, scientists emphasize that more clinical trials are needed to determine the safest and most effective forms and dosages.

包括鸟氨酸α-酮戊二酸在内的不同形式的AKG在动物和人类研究中显示出减轻炎症和改善肠道健康的希望。然而，科学家强调，还需要更多的临床试验来确定最安全和最有效的形式和剂量。

Conclusion

结论

The growing body of research suggests that AKG is far more than a simple metabolic compound. It acts as a central regulator linking energy production, inflammation control, and genetic activity. Its ability to influence such a wide range of biological processes makes it a highly promising target for future therapies.

研究表明，AKG 不仅仅是一种简单的代谢化合物，它充当了连接能量生产、炎症控制和基因活动的中心调节器。其影响广泛生物过程的能力使其成为未来治疗中非常有前景的目标。

However, its effects can vary depending on the condition and cellular environment, meaning careful research is still required before widespread medical use. With further study, AKG could become a key player in treating aging-related diseases, chronic inflammation, and metabolic disorders..

然而，其效果会因疾病状况和细胞环境的不同而有所差异，这意味着在广泛用于医学治疗之前仍需进行谨慎的研究。通过进一步的研究，AKG有望成为治疗与衰老相关的疾病、慢性炎症和代谢紊乱的关键角色。

The study findings were published in the peer reviewed journal: Biomedicines.

研究结果发表在同行评审期刊《生物医学》上。

https://www.mdpi.com/2227-9059/14/4/836

https://www.mdpi.com/2227-9059/14/4/836

For the latest anti-aging and anti-inflammatory solutions, keep on logging to Thailand

为了最新的抗衰老和抗炎解决方案，继续登录泰国。

Medical News

医学新闻

.

。

Read Also:

另请阅读：

https://www.thailandmedical.news/articles/anti-aging

https://www.thailandmedical.news/articles/anti-aging