THURSDAY, May 2, 2024 -- An experimental cancer vaccine can quickly reprogram a person’s immune system to attack glioblastoma, the most aggressive and lethal form of brain cancer, a small, preliminary study has found.The cancer vaccine is based on mRNA technology similar to that used in COVID vaccines, but in this case a patient’s own tumor cells are used to create a personalized vaccine, researchers said.The vaccine teaches the immune system to see tumor cells as a dangerous virus, prompting a vigorous immune response against the cancer, researchers said.One of the most impressive results was how quickly the injectable vaccine turns the immune system against a brain tumor, said senior researcher Dr.

2024年5月2日，星期四——一项小型初步研究发现，一种实验性癌症疫苗可以快速重新编程一个人的免疫系统，从而攻击胶质母细胞瘤，这是最具侵略性和致命性的脑癌形式。研究人员说，这种癌症疫苗基于类似于新型冠状病毒疫苗的mRNA技术，但在这种情况下，患者自己的肿瘤细胞被用来制造个性化疫苗。研究人员说，这种疫苗教会免疫系统将肿瘤细胞视为一种危险的病毒，从而引发针对癌症的强烈免疫反应。高级研究员Dr。

Elias Sayour, a pediatric oncologist with University of Florida Health who pioneered the new vaccine.In a first-ever human clinical trial with four adult patients, the vaccine prompted a quick and apparently effective immune attack on cancer.“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’ -- immune cold, very few immune cells, very silenced immune response -- to ‘hot,’ very active immune response,” Sayour said in a university news release.“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” Sayour added.The results mirror those seen in 10 pet dogs with brain tumors who served as early test subjects, as well as lab mice.

佛罗里达健康大学的儿科肿瘤学家EliasSayour是这种新疫苗的先驱。在对四名成年患者进行的首次人体临床试验中，该疫苗引发了对癌症的快速且明显有效的免疫攻击。Sayour在一份大学新闻稿中说：“不到48小时，我们可以看到这些肿瘤从我们所说的‘冷’——免疫冷，免疫细胞很少，免疫反应非常沉默——转变为‘热’，非常活跃的免疫反应。”。Sayour补充道：“鉴于这种情况发生得如此之快，这非常令人惊讶，这告诉我们，我们能够非常快速地激活免疫系统的早期部分来对抗这些癌症，这对于解开免疫反应的后期影响至关重要。”。结果与10只患有脑肿瘤的宠物狗以及实验室小鼠的早期测试结果一致。

Dogs offer a natural opportunity to test brain cancer therapies because they’re the only other species that regularly develops brain tumors, the researchers explained.The vaccine now will be tested in a phase 1 pediatri.

研究人员解释说，狗为测试脑癌疗法提供了一个自然的机会，因为它们是唯一经常发生脑肿瘤的其他物种。该疫苗现在将在第一阶段儿科进行测试。